3D matrix for mesenchymal stem cells (MSC)

DESCRIPTION

• 3D matrix made of alginate and chitosan complexes suitable for MSC culture and displaying the following in vitro features:
  - Preservation of cell phenotype
  - Preservation of MSC viability to c.a. 80% after 1 month
  - Preservation, or even increase, of the paracrine secretory capacity of the MSC compared to 2D cultures
• Production process compatible to GMP standards while controlling the architecture
• In vivo property: excellent biocompatibility, significant improvements of the cardiac function and of the neovascularization of the infarcted tissue, limitation of the ventricular fibrosis

APPLICATIONS

• In vitro cellculture
• Cell therapy based on paracrine effect, especially in the field of cardiology