ANTISYN: prevent the development of intra-uterine synechia in order to regain fertility spontaneously

Design of a medical device that is bioresorbable, anti-adhesion, and self-deploying, adapted for an endo-uterine approach, to prevent the development of intra-uterine synechia in order to regain fertility spontaneously

CONTEXT

Uterine synechia correspond to intra-uterine adhesion. They are a relatively common reason for medical consultation, notably because of the reproductive and/or menstruation issues they cause for women. Their development is cause by two main factors:

• An intra-uterine surgical procedure provoking irritation in the endometrium and intra-uterine cavity.

• An infection contracted during a surgical intervention (IUD placement), or due to a pathology (such as tuberculosis).

The objective of the ANTISYN project is to design and evaluate an intra-uterine medical device that provides a temporary anti-adhesion effect. This device seeks to resolve the issue represented by fertility failures in patients who have undergone endo-uterine procedures.

At this time, no commercially available medical device meets the expectations of clinical practitioners entirely. The expertise developed by this project stands out for its ability to make the device match the properties of synthesized polymers with the properties sought by gynecological surgeons. This project is situated at the border between applied biomaterials research and clinical gynecological applications.

BENEFITS

- Physical barrier that keeps the uterine walls separated during the first days following surgery (5 to 7 days), without affecting the proper regeneration of the endometrium.

- Anti-adhesion properties that prevent the adhesion and proliferation of fibroblasts.

- Ease of implantation with adapted deployment and inflation properties. Painless deployment for the patient, without obstructing the cavity or affecting the flow of biological fluids.

- Medical device using a resorbable polymer, eliminated by natural means 5 to 7 days following the surgical act.

- Painless elimination of the device by the patient, without any effect on menstruation or reproduction.

- Medical device made of a biocompatible polymer that is non-toxic and non-immunogenic.

APPLICATIONS

Implantable medical equipment, usable by all gynecological practitioners as prevention to avoid the development of intra-uterine synechia in order to regain fertility spontaneously.