Prevention and/or treatment of prosthesis-related infection in :
The problem : Prosthesis-related infection is a serious complication for patients, which is currently difficult to treat with classical antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection.
This project aims to develop orthopedic implants based on titanium functionalized with intelligent antibiotic systems. Antibiotic release systems (widely used to prevent infections during orthopedic surgery) are controlled by a change in pH on bone implants typically observed in bacterial infections.
Patent applications: WO 2016/097358 A1, WO 2006/008386 A1, WO 2006/008387 A1
Maturation with Aquitaine Science Transfert showed the possibility of synthesizing bioactive implants allowing the release of an antibiotic only in case of infection