Contrasting agent for multimodal imaging

DESCRIPION

• Nanoparticles combining polymers and ions classically used in medical imaging settings such as lanthanides or metallic ions (even radioactive)
• Immediate production process, of a one-pot aqueous-based reaction, potentially available as a kit, leading to particles with the following features:
  - Mono-disperse within a controllable size range (10 to 40nm)
  - Stable to freeze-drying, and to a wide range of temperature, ionic strength and physiological pH
  - Extendable to multimodal imaging
• Improvement of standard MRI contrasting features:
  - Increased relaxivity: r1 = 15,4 vs. 4,8 for DOTAREMTM at 7T
  - Improved in vivo contrast (in rat) with a 3-fold decreased concentration compared to DOTAREMTM
• Good tissue distribution and delayed elimination
• Very good biocompatibility:
  - Neutral apparent charge (zeta potential = 0mV)
  - Excellent tolerance in rat (15µg/kg)

APPLICATIONS

• Non-invasive andperoperative imaging
• High field medical imaging
• Multimodal imaging (MRI/optical/TEP)