The present offer relates to the development of new type of gels, based on polysaccharides or denatured collagen, which are able to successively undergo sol-gel and then gel-sol controlled transitions under the action of two customized antagonistic enzymes, i.e. transglutaminase and protease. These gels are biodegradable after a determined time without any change in temperature or medium composition due to the defined concentrations and ratio between the two enzymes. This unique technology enables to fine-tuned and controlled release of small and large molecules or proteins, from 200 Daltons to 2 Million Daltons. These gels are easy to produce, handle and store. In healthcare area, it could be used as an original wound care system or a new dynamic and controlled drug delivery system. For example, antibacterial agent delivery could confer to the system a specific anti-biofilm activity. The potential of usage of these gels could also bring solutions in cosmetic area.
Keywords : Controlled release of active molecules, Wound care system, Drug delivery system, Topical application