ENZGEL : A DYNAMIC HYDROGEL WITH FINE-TUNED AND CONTROLLED RELEASE OF ACTIVE MOLECULES

The present offer relates to the development of new type of gels, based on polysaccharides or denatured collagen, which are able to successively undergo sol-gel and then gel-sol controlled transitions under the action of two customized antagonistic enzymes, i.e. transglutaminase and protease. These gels are biodegradable after a determined time without any change in temperature or medium composition due to the defined concentrations and ratio between the two enzymes. This unique technology enables to fine-tuned and controlled release of small and large molecules or proteins, from 200 Daltons to 2 Million Daltons. These gels are easy to produce, handle and store. In healthcare area, it could be used as an original wound care system or a new dynamic and controlled drug delivery system. For example, antibacterial agent delivery could confer to the system a specific anti-biofilm activity. The potential of usage of these gels could also bring solutions in cosmetic area.

Competitive advantages:

• Elastic and biodegradable hydrogel,
• Enzyme controlled sol/gel/sol transitions allowing a timecontrolled
  conformation change
• Customized fine-tuned and controlled release of active molecules
• Easy to produce, handle and store (sterilization and lyophilization)

Applications:

• Adapted for healthcare - Wound care
  management
• Topical drug delivery system of active
  molecules
• Cosmetic applications

Keywords : Controlled release of active molecules, Wound care system, Drug delivery system, Topical application