Fields
Biology / MedicalSectors
Health
The present invention is based on an optimized liposomal formulation to improve targeting and maturation of dendritic cells.
The liposome membrane bears a well-defined mannose motif in order to specifically target DC membrane receptors. This motif has the inherent ability to activate DCs, thereby facilitating antigen presentation and immune response initiation.
Consequently, these DC-targeting liposomes greatly improve the efficacy of mRNA vaccines.