Mannosylated liposomes to improve mRNA-based therapeutic vaccination

SATT LUTECH



22 Janvier 2016

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Fields

Biology / Medical

Sectors

Health

The present invention is based on an optimized liposomal formulation to improve targeting and maturation of dendritic cells. 

The liposome membrane bears a well-defined mannose motif in order to specifically target DC membrane receptors. This motif has the inherent ability to activate DCs, thereby facilitating antigen presentation and immune response initiation.

Consequently, these DC-targeting liposomes greatly improve the efficacy of mRNA vaccines.  

 

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