NEW MULTI ELECTRONS BASED ELECTROCHEMICAL PROBES

DESCRIPTION
The laboratory has synthesized a new phosphoramidite synthon compatible with the conditions of DNA synthesis. The derivative is incorporated at the end or in any position of the oligonucleotide chain by solid phase chemistry. An important number of synthons can be incorporated in the probe. This new kind of electrochemical probe is more sensitive thanks to the transfer of the 2 electrons per molecule and more stable than ferrocene modified ones.

STAGE OF DEVELOPMENT
Proof of concept was validated with a gold electrode biosensor. The laboratory masters know-how relating to synthesis, purification and grafting of probes

INTELLECTUAL PROPERTY
Patent pending in FR
Priority date: February 27, 2012 (FR12 51739

ADVANTAGES / NOVELTY
Nucleotide based electrochemical biosensors for:
• Health: detection microsystem for point of care specific analysis
• Environment
• Food industry

APPLICATIONS
• Electrochemical microsystem more sensitive for target detection and more stable in oxidative conditions
• Improvement of marker performance : transfer of 2 electrons by oxidation wave
• Direct detection, real time
• Reusable system

COLLABORATION TYPE
PULSALYS offers to grant patent license and looks for industrial partners

CONTACT
Christian CHAPELLE
Email: christian.chapelle@pulsalys.fr
Tel: +33(0)4 26 23 56 70