NOVEL ANTITUMORAL SMALL MOLECULE

There is a need for new, efficacious anticancer agents associated with increased response rates and with limited and manageable toxicity. The present offer proposes a novel chemical compound with antiproliferative and anti-vascular properties validated in vitro and in vivo. This compound has shown high efficient anti-cancer potency in in vitro models using 24 cancer cell lines (some of them being resistant to chemotherapies). In vivo, this compound has shown a tumor volume reduction of 80-95% on lung and colon murine tumors with no major identified side effects.

Competitive advantages:

• New chemical entity
• Water soluble, stable and easy to synthetize
• High efficiency in 24 different in vitro cell lines including multidrug
  resistant ones
• Better efficacy than the anti-vascular comparator combretastatin
  CA4

Applications:

• Treatment of solid tumors, in particular in colon, lung, ovaria, uterus

Keywords:

Cancer, Anti-proliferative, Anti-Vascular, Tumor Therapy, Small molecule