OXYGEN EFFECT IN TREATMENT PLANNING SYSTEM FOR RADIOTHERAPY AND HADRONTHERAPY

DESCRIPTION
Based on the most up-to-date Monte-Carlo simulations of the production of Reactive Oxygen Species (ROS) by radiation, including X-rays and ions from protons to ions heavier than carbon ions, our solution enables to extend any TPS (Treatment Planning System) by including the level of oxygenation in tumours (from hypoxia to normoxy). This solution offers the possibility to recalculate the actual cell survival of tumor cells or to define an effective biological dose according to the cartography of oxygen level and of physical dose in patient tumour (or distribution of (Z, E) for proton and carbon therapies).Then, the treatment plan
can be re-optimized for a higher effect in tumour but with lowest doses in healthy tissues. The only required inputs are some parameters to describe the
response of cells to X-rays at two oxygenation levels only.

STAGE OF DEVELOPMENT
Needs for validation of the solution with extensive experimental data.

ADVANTAGES / NOVELTY
• One solution for different radiation qualities (X-rays, proton to carbon ions)
• Possible coupling with any TPS solution
• Based on up-to-date description of ROS
• Production
• For ions, take account for both LET (Linear Energy Transfer) and Z (Charge)

INTELLECTUAL PROPERTY
Patent pending in PCT
Priority date: November 15, 2012 (FR12 60892)

COLLABORATION TYPE
PULSALYS looks for industrial partners and offers to grant patent license

CONTACT
Laëtitia ROUX
Tech Transfer Officer
Tél. : +33 (0) 4 26 23 56 65
laetitia.roux@pulsalys.fr