QAFSI: Automatic device for diagnosis, prognosis and monitoring of acute and chronic organ transplant rejections


25 Novembre 2015

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Biology / Medical



Current quantification technique is based on the subjective analysis by a pathologist of stained slides from biopsies. It requires a significant phase for sample preparation and is not reproducible due to the great variability intra and between operators. It does not allow you to access certain data such as the distinction between fibrosis and constituent collagen causing a significant overestimation of the fibrosis level. No automated technique allows quantifying active inflammation without marking.


Low cost due to the complete automation requiring:

  • A small technical time ~ 5 minutes,
  • No sample preparation,
  • No engineer time needed,
  • No medical time for analysis

Diagnostic contribution: precise quantification of active inflammation and classification i

Prognosis: precise quantification of fibrosis enabling IC and FIAT classification.
Repeatable: allows the monitoring of patients and could make possible the realization of international studies.
Specific to pathological collagen: no overvaluation of fibrosis rate
Acquisition time:

  • comparable to a plate scanner: 1 to 1,5 hour depending on the resolution and on sample
  • This time could be reduced to 30 minutes by coupling detectors.

Low data volume: 600 MB for a cutting with a resolution of 25μM/cm²

Direct reading of the rates of: fibrosis, active inflammation, normal parenchyma, constituent collagen.

Direct reading of: the IC Interstitial fibrosis score, the I score of Interstitial Inflammation, the confidence index

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