Specific peptides to filter out autoantibodies to citrullinated proteins (ACPA)

DESCRIPTION

• Strong rationale for involvement of fibrin/ACPA immune complexes in self-maintaining of joint inflammation
• Peptide constructs derived from human fibrin bearing the immunodominant epitopes targetted by ACPA
• Use of the constructs for therapeutic purposes includingremoval of ACPA
• Efficiency of the constructs for ACPA elimination validated by affinity chromatography with large series of sera showing various profiles of ACPA specificities

APPLICATIONS

• Therapeutic strategies for rheumatoid arthritis