Synthesis of new TACN precursors: an efficient route to TACN and its N/C functionalized derivatives

Presentation

This is a synthesis method for the preparation of imadazo [1,2-a]pyrazin4-ium salts (compounds V’) used for the synthesis of TACN and N– and/or C-functionalized derivatives (formula I).

Competitive advantages

• Cost-effective synthesis;
• More efficient synthetic process: less waste, less steps;
• Access to a new family of bifunctional chelators (C-functionalized derivatives).
  

Applications/Markets

• Chelators able to form stable complexes with metals;
• Biomolecules (antibodies, peptides, aptamers) labeling for SPECT and PET imaging dedicated to RadioImmunoTherapy (RIT);
• Building blocks for the preparation of multimodal probes and theranotics;
• Treatment of liquids (elimination of metallic elements trace), decontamination of radioactive effluents and elimination of toxic heavy metals;
• Precursors of metallic complexes as catalyst for oxidation reactions.

Intellectual property

• Technology protected by patents (US, EU, and France);
• Out-licensing available.