06 Août 2020

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Engineering NICT


Measurement & Instrumentation

Innovative tool to model the dynamic of genetic systems



Market Challenges
Computational biology refers to the development of techniques for the collection, manipulation, and use of biological data to make discoveries and predictions.
Combining biology and computers, it aids in drug breakthroughs and consequent development during the various stages of clinical trials.
However, factors such as absence of standardization, limiitations of individual methods, lack of skilled resources and personnel, shortage of data, and non-verified predictive models are expected to challenge market penetration.

Innovative solution
A team from Sorbonne Université has developed a modeling software and multilayer network approach that can handle complete molecular profile datasets (e.g. RNA-seq, proteomics, RNAi screens) to bring out what are the essential responses of biological systems to disease.
This software is based on a data-driven approach in which the dynamics of signaling systems is weighted across conditions (e.g. across layers of molecular regulation, across time-points). The software enables to visualize the temporal dynamics of genetic interactions and select top targets to optimize the development of new treatments.

Development status
Accurate model of the molecular and temporal dynamics of the Huntington’s disease (HD) process in the mouse striatum and cortex.
Top predictions about genetic interactions validated in C. elegans models of neuronal dysfunction in HD.
Top predictions about genes centrally involved in the HD process validated in cellular models of the disease.

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