{"id":41297,"date":"2024-04-24T13:00:07","date_gmt":"2024-04-24T11:00:07","guid":{"rendered":"https:\/\/www.satt.fr\/?p=41297"},"modified":"2024-04-24T13:18:35","modified_gmt":"2024-04-24T11:18:35","slug":"rebrain","status":"publish","type":"post","link":"https:\/\/www.satt.fr\/en\/rebrain\/","title":{"rendered":"La Success Story du mois : REBRAIN"},"content":{"rendered":"
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#De la recherche acad\u00e9mique en math\u00e9matiques et en neurosciences \u00e0 une success-story en neurochirurgie<\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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\u00c0 peine trois ans apr\u00e8s sa cr\u00e9ation, la med-tech bordelaise RebrAIn, sp\u00e9cialis\u00e9e dans le traitement des maladies de Parkinson et du tremblement essentiel, vient d\u2019annoncer la lev\u00e9e de 3,7 millions d\u2019euros pour se d\u00e9velopper commercialement \u00e0 l\u2019international, avec en premi\u00e8re ligne de mire, le march\u00e9 am\u00e9ricain. La start-up veut aussi mettre l\u2019accent sur la R&D et d\u2019autres modes de traitement comme les ultrasons focalis\u00e9s de haute intensit\u00e9 ou la radiochirurgie.<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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Dans le domaine de la neurochirurgie, les innovations naissent g\u00e9n\u00e9ralement au c\u0153ur des Centres Hospitaliers Universitaires (CHU) et des laboratoires de recherche publics. La start-up RebrAIn en est un parfait exemple, en r\u00e9volutionnant la mani\u00e8re dont les neurochirurgiens pourront cibler les zones c\u00e9r\u00e9brales pour traiter des maladies neurod\u00e9g\u00e9n\u00e9ratives telles que la maladie de Parkinson et le tremblement essentiel.<\/p>\n

Fond\u00e9e en 2021, RebrAIn<\/a> est le fruit d'une collaboration entre Emmanuel Cuny, professeur de neurochirurgie \u00e0 l'universit\u00e9 de Bordeaux et praticien au CHU de Bordeaux, et Nejib Zemzemi, docteur en math\u00e9matiques appliqu\u00e9es. Leur objectif \u00e9tait de mettre au point un dispositif intelligent m\u00ealant chirurgie et plateforme logicielle (OptimDBS), visant \u00e0 am\u00e9liorer la pr\u00e9cision du ciblage chirurgical pour la Stimulation C\u00e9r\u00e9brale Profonde (SCP).<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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R\u00e9volutionner le traitement des maladies neurod\u00e9g\u00e9n\u00e9ratives<\/strong><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div>
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La SCP est une m\u00e9thode de traitement invasif qui implique l'implantation d'\u00e9lectrodes dans le cerveau. Ces \u00e9lectrodes sont connect\u00e9es \u00e0 un dispositif sous-cutan\u00e9 qui \u00e9met un courant \u00e9lectrique de faible intensit\u00e9 vers des structures c\u00e9r\u00e9brales sp\u00e9cifiques. Cette neurochirurgie n\u00e9cessite une \u00e9lectrophysiologie perop\u00e9ratoire pendant laquelle le patient est maintenu \u00e9veill\u00e9 pour identifier les emplacements o\u00f9 implanter les \u00e9lectrodes.<\/p>\n

Les deux chercheurs ont con\u00e7u un algorithme d\u2019intelligence artificielle permettant identifier 25 points fixes dans le cerveau pour d\u00e9terminer avec pr\u00e9cision l\u2019endroit de placement des \u00e9lectrodes de stimulation, un peu comme le fait un GPS. A partir des donn\u00e9es IRM, des sp\u00e9cifications du praticien et des caract\u00e9ristiques du patient, l'algorithme localise une ou deux emplacements pour les \u00e9lectrodes sur une imagerie 3D. Le neurochirurgien utilise ensuite ces informations pour planifier et ex\u00e9cuter l'intervention avec une pr\u00e9cision accrue.<\/p>\n

Ce dispositif, prot\u00e9g\u00e9 par un brevet et un d\u00e9p\u00f4t logiciel, ne se distingue pas seulement par son potentiel d'am\u00e9lioration des r\u00e9sultats cliniques, mais aussi dans sa capacit\u00e9 \u00e0 rendre les proc\u00e9dures neurochirurgicales moins co\u00fbteuses et moins traumatisantes pour les patients. La facilitation du processus chirurgical qu'il permet est un atout majeur qui facilite l'acc\u00e8s \u00e0 des traitements avanc\u00e9s pour un plus grand nombre de patients.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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Un projet soutenu par la SATT Aquitaine Science Transfert<\/strong><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Dans leur parcours, les deux chercheurs ont \u00e9t\u00e9 fortement soutenus par la SATT Aquitaine<\/a>, qui a investi 226 000 euros dans propri\u00e9t\u00e9 intellectuelle et dans la maturation de la preuve de concept, tant technique que clinique. Inria a \u00e9galement apport\u00e9 un soutien financier et technologique crucial, avec un investissement initial de 100 000 euros pour le d\u00e9veloppement du logiciel OptimDBS, particuli\u00e8rement sur l'intelligence artificielle qui apprend continuellement \u00e0 am\u00e9liorer la pr\u00e9cision du ciblage des zones c\u00e9r\u00e9brales.<\/p>\n

OptimDBS a obtenu la certification europ\u00e9enne CE, ainsi que l\u2019autorisation de la FDA am\u00e9ricaine. Il est d\u00e9j\u00e0 utilis\u00e9 dans des centres hospitaliers en Espagne et en Italie, mais aussi en France o\u00f9 les centres hospitaliers de dix grandes villes se sont engag\u00e9s \u00e0 conduire une \u00e9tude clinique m\u00e9dico-\u00e9conomique.<\/p>\n

La success story de RebrAIn est un nouveau t\u00e9moignage la capacit\u00e9 de la recherche publique fran\u00e7aise \u00e0 g\u00e9n\u00e9rer des avanc\u00e9es technologiques qui r\u00e9pondent \u00e0 des enjeux soci\u00e9taux majeurs. Elle illustre \u00e9galement le r\u00f4le primordial que jouent les SATT dans le soutien tr\u00e8s t\u00f4t \u00e0 l'innovation et \u00e0 l'entrepreneuriat en France.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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D\u00e9couvrir Rebrain<\/span><\/span><\/strong><\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

#De la recherche acad\u00e9mique en math\u00e9matiques et en neurosciences \u00e0 une success-story en neurochirurgie \u00c0 peine trois ans apr\u00e8s sa cr\u00e9ation, la med-tech bordelaise RebrAIn, sp\u00e9cialis\u00e9e dans le traitement des maladies de Parkinson et du tremblement essentiel, vient d\u2019annoncer la lev\u00e9e de 3,7 millions d\u2019euros pour se d\u00e9velopper commercialement \u00e0 l\u2019international, avec en premi\u00e8re ligne […]<\/p>\n","protected":false},"author":2,"featured_media":41296,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[567],"tags":[],"class_list":["post-41297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en"],"acf":[],"yoast_head":"\nLa Success Story du mois : REBRAIN - R\u00e9seau SATT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.satt.fr\/en\/rebrain\/\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.satt.fr\/en\/rebrain\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.satt.fr\/en\/rebrain\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/www.satt.fr\/en\/#\/schema\/person\/6f20a7d0bc03146f6e34a9f08d941fec\"},\"headline\":\"La Success Story du mois : REBRAIN\",\"datePublished\":\"2024-04-24T11:00:07+00:00\",\"dateModified\":\"2024-04-24T11:18:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.satt.fr\/en\/rebrain\/\"},\"wordCount\":691,\"image\":{\"@id\":\"https:\/\/www.satt.fr\/en\/rebrain\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.satt.fr\/wp-content\/uploads\/2024\/04\/la-successstory-du-mois-3.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.satt.fr\/en\/rebrain\/\",\"url\":\"https:\/\/www.satt.fr\/en\/rebrain\/\",\"name\":\"La Success Story du mois : REBRAIN - 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