Dengue virus (DENV) in one of four serotypes is the cause of dengue fever. All four serotypes (DENV-1 to 4) can cause the full spectrum of disease.
Dengue is the most rapidly spreading mosquito-borne viral disease in the world. In the last 50 years, incidence has increased 30-fold.
Immunization against one of the serotypes does not immunize against the 3 other ones.
An estimated 50-100 million dengue infections occur annually and approximately 2.5 billion people live in dengue endemic countries (more than 110 endemic countries).