LSR : Inflammatory and neurological diseases

SATT NORD



15 Mai 2015

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Fields

Biology / Medical

Sectors

Health

The Sigma-1 receptors (σ1R) correspond to a single class of transmembrane receptors located into endoplasmic reticulum.
Expressed in the central nervous system and more particularly in neurons and oligodendrocytes, these receptors are known to be involved in the regulation of many neurotransmitters and diseases such as neurodegenerative diseases, cancer, inflammatory diseases, pain and neurological
diseases.
A new family of molecules with a new structure demonstrated in vitro efficacy, selectivity and low cytotoxicity. In vivo results confirm the therapeutical potential of this new family

Benefits:

- New family of ligands for Sigma-1 receptors with a good affinity and selectivity.
- The synergistic effect of Sigma-1 receptors (neuro-protection, degeneration, inflammation) is leading to a putative therapeutic impact in neurodegenerative and
inflammatory diseases.

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