This technology relates to novel aminopyridinemethanol compounds, obtained by an enantioselective synthesis.
This family compounds demonstrated a strong antimalarial activity at nanomolar concentrations.
- A strong antimalarial activity on Plasmodium falciparum strains W2 (resistant to chloroquine) and 3D7 (resistant to mefloquine) is observed and no cross-resistance was detected neither with mefloquine, nor with chloroquine
- These compounds are more active than chloroquine and mefloquine whatever the strain
- In addition, these compounds are devoid of clastogenic and/or aneugenic activities and devoid of mutagenic activity
These compounds will be useful in the prevention and/or treatment of malaria