Using patient-specific neuronal cells is a promising approach for the diagnosis and treatment of neurodegenerative diseases and for scientific research. However, current methods to produce or extract neuronal cells are highly invasive or drastically alter the cell genome. The present offer proposes a new method, alternative to iPS, for differentiating white blood cells, extracted from fresh human blood, into neuronal-like cells without cell reprogramming. The resulting
cells structurally resemble neurons, present spontaneous electrical activity and express a wide variety of neuronal markers. A 40% differentiation-rate, within 3 weeks, was reached following a simple and robust protocol (developed at Cochin Institute and Sainte-Anne Hospital). This method can be used to generate in vitro models of neuropathologies for drug discovery.
Competitive advantages :
Keywords : Neuronal-like cells, Transdifferentiation, Neurodegenerative diseases, Research tool