Around 1 million in vitro fertilizations (IVF) are performed each year worldwide with a success rate of only 25%.
To increase the chances, 2 or 3 embryos can be implanted, inducing a risk of multiple pregnancy (20% of IVF) that can cause an increased fetal mortality and maternal complications.
Up to now, the embryo morphology evaluation is the only method of screening. A better prognosis assessment of implantation is needed in order to implant a single embryo without impacting the chances of pregnancy.
We have identified a predictive biomarker to select the embryos showing the highest implantation potential
This glycoprotein -secreted in the embryo supernatants- is a new factor regulating embryo implantation
Comparison of glycoprotein concentrations between implanted (n=63) vs. non-implanted embryos (n=172) showed a significantly lower concentration in embryos that are implanted (p=0.0001). A multivariable analysis confirmed the significant association between a low biomarker concentration and implantation (p=0.02).
Pre-implantation test for in vitro fertilization