The limitations of current recombinant protein production systems include: the use of a transcription inducer and specific medium, low yield, high costs and complex industrial scaling.
To overcome these difficulties, we have developed a new self-inducible recombinant protein production system. Our technology is based on a SILEX (Self-InducibLe EXpression) plasmid able to transfer to a bacteria the ability to induce autonomously heterologous protein expression without the use of a chemical inducer and a specific culture medium. SILEX can be used from microliter to large production scales and is compatible with a wide range of existing plasmids.
MARKETS & APPLICATIONS
Biotechnology : production of recombinant proteins at laboratory (research community and commercial suppliers) or industrial scale (pharmaceutical, agri-food industry...)
Technology tested i) on over 40 heterologous proteins, ii) with over 10 media and iii) on 96-well plates with volumes as low as 25μl
"Centre des Sciences du Goût et de l'Alimentation" (Dijon, France)
Patent WO2016046137 (09/2014): granted in the USA, European grant in progress in France and Belgium
Patent licensing or services in protein production
Business Development Manager
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