Novel neurosteroid drug candidates for the treatment of chemotherapy-induced painful neuropathies

Analogs of the natural non-toxic allopregnanolone to eradicate neuropathic pain with expected reduced side-effects 

TECHNOLOGY

• Based on Lab findings that the natural neurosteroid allopregnanolone, devoted on toxic side-effects in human, prevents and eradicates neuropathic symptoms evoked in rats by VINC and OXAL
• Identification of chemically optimized analogs that display a potent neuroprotective effect without proliferative action on human neuroblastoma SHSY5 cells

APPLICATIONS

• Prevention and treatment of painful neuropathies
• In combination to cancer chemotherapy to prevent/suppress drug-evoked neuropathies

INNOVATION ADVANTAGES

• Novel MOA preventing and repairing lesions responsible for neuropathic pain
• Expected to be safe, as analogs of the allopregnanolone

DEVELOPMENT STATUS

• First in vivo POC in VINC-induced allodynia rat model
• Ongoing determination of PD parameters and non-toxic profile after oral administration in various animal models (prophylactic and therapeutic indication)