QC certification system for antibodies dedicated to genome-wide studies and associated database

First quantifiable measurement for the quality of sequencing datasets obtained by massive parallel sequencing and the quality of the reagents used for the profiling.

TECHNOLOGY

• Bioinformatic tool generating both global and local numerically defined quality control (QC) parameters for genome-wide NGS profiling data sets. This QC system is applicable to all NGS-based profiling and to certification process of antibodies dedicated to genome-wide studies
• Database comprising a 2-dimensional representation of the global QC parameters

APPLICATION

Quality control of NGS profiling and quality control of the reagents used for the profiling

INNOVATION ADVANTAGES

This appoach allows:

• The attribution of a quality label to the profiling
• The determination of the optimal sequencing depth
• The determination of the best method to implement for a given sample
• First QC of antibodies dedicated to genome-wide studies based on quantitative descriptors
• Possibility to give insights for the improvement of the quality of NGS data obtained with a given antibody

DEVELOPMENT STATUS

• Fully automated pipeline for the QC of client antibodies:
  • Highly reproducible procedure with lowest possible variability
• Comprehensive database hosting currently >20k datasets:
  • A powerful source for the quality control certification of antibodies used in NGS-generated dataset