Reversible Native Chemical Ligation: From Dynamic Peptides to Peptides Drug Discovery platform

• Novel dynamic combinatorial peptidic systems occurring:
  • In mild conditions & neutral pH
  • By using N-Methylated-Cysteine moities as reversible bond effector
• Patented Drug Discovery tool, highlighted in Nature ScBX

TECHNOLOGY

• Use of reversible oriented native chemical ligations at the non-natural amino acid N-Methyl-Cysteine (Nme-Cys)
• A combinatorial dynamic chemical library, in the presence of a substrate, lead to a disruption of the equilibrium, generating the most stable/affine entity

APPLICATION

• Straightforward single experiment Drug Discovery/Optimization tool for:
  • Proteins/Receptors, Adaptative Antibodies discovery
  • Biological targets peptide-based ligands

INNOVATION ADVANTAGES

• Screening of millions of potential peptides combinations in one experiment, mild conditions, neutral pH, with biologically relevant Nme-Cys amino-acid
• Unprecedented & Fast dynamic covalent peptides screening
• Combination of rational & phenotypic approaches