Cardioprotection after myocardial infarction

L'innovation

Microparticles (MPs) are small fragments generated from the plasma membrane after cell stimulation. Membrane microparticles (MPs) derived from activated/apoptotic T lymphocytes harbor Sonic-HedgeHog (MPSHh+) are able to regulate in vitro angiogenesis.

We demonstrate :

- In vivo injection of MPSHh+ in mice improves endothelial function by increasing NO release, and it reverse endothelial dysfunction after ischemia/reperfusion.
- In mice and porcine myocardial infarction model, injection of MPSSHh reduces infarct size and reperfusion arrhythmias via a prevention of QT enlargement.
- MPSSHh via Shh signaling pathway protect the myocardium against the reperfusion injuries after an acute myocardial infarction.

Ses bénéfices
Low side effects
Reduction of infarct size
Reduction of reperfusion arrhythmias

Ses applications
Cardioprotection after myocardial infarction

Stade de développement
IN VIVO - Preuve de concept

Laboratoire de recherche
UMR_S 1063 - SOPAM

Équipe de recherche
Stress Oxydant et Pathologies métaboliques

Propriété intellectuelle associée
EP : EP13305029 - filed on the 01-14-2013
WO - DE,EP,ES,FR,GB,IT,JP,US,US