IF1: a new HDL-related biomarker

DESCRIPTION

• Inhibitor Factor 1 (IF1): a blood-based biomarker of HDL-C functionality to evaluate the risk of coronary artery disease
• Polyclonal antibody against IF1 allowing the development of an ELISA kit/automated assay
• Clinical validation on the GENES cohort:
  - Case-control study evaluating the risk of developing coronary heart disease: 648 patients (45-74 years old) vs. 669 male controls
  - Evaluation of the long-term (10-year) prognosis in coronary artery disease: 577 male patients (45-74 years old)
• Additional discrimination compared to patients exhibiting low apoA-I levels

APPLICATIONS

• Evaluation of cardiovascular diseases (coronary artery disease, peripheral artery disease, etc.):
  - Risk of occurrence
  - Measurement of seriousness
  - Evaluation of therapy efficiency