IL4I1 is an immunosuppressive enzyme highly expressed in all cancers by infiltrating macrophages and in some cases, such as B lymphomas and mesotheliomas, by tumor cells. Its expression in the tumor bed favors immune escape. This process might result in a defective response to immunotherapy in cancers, in particular in the cases, which have failed or become resistant to anti-checkpoint treatments. We propose specific inhibitors of enzyme IL4I1 to enhance the anti-tumor immune response.
Keywords: Cancer, Anti-tumor, Immunomodulation, Immunosuppressive enzyme, IL4I1, Immunotherapy