BACKGROUND

Fire Blight: contagious disease affecting apples, pears, crabapples, quince, and some other members of the family Rosaceae.

One of the most dangerous bacterial attack.

The causal pathogen is Erwinia pathogen, and specifically Erwinia Amylovora, a Gram-negative bacterium in the family Enterobacteriaceae.

No existing efficient treatment.

TECHNOLOGY

Innovative mechanism of action: hydrolysis of lactones molecules involved in the inter-bacteria communication and virulence factors (quorum sensing inhibition)

 Activity:

• Ability to inhibit biofilm formation and virulence factor production by P. aeruginosa

• Activity on Erwinia Amylovora demonstrated in literature on lactonase

 Safety: No toxicity on rats observed up to 10mg/ml

KEY BENEFITS

• The most active lactonase among all described lactonases

• Highly thermostable (Tm = 106 °C),

• 1,000 times more resistant than the mesophile lactonase to protease

• Stable more than 1 year in liquid buffer and more than 5 years after freeze- drying

• Cost effective

• Eco-friendly

APPLICATIONS

Fire blights infections

• Prevention

• Treatment