Fire Blight: contagious disease affecting apples, pears, crabapples, quince, and some other members of the family Rosaceae.
One of the most dangerous bacterial attack.
The causal pathogen is Erwinia pathogen, and specifically Erwinia Amylovora, a Gram-negative bacterium in the family Enterobacteriaceae.
No existing efficient treatment.
Innovative mechanism of action: hydrolysis of lactones molecules involved in the inter-bacteria communication and virulence factors (quorum sensing inhibition)
Ability to inhibit biofilm formation and virulence factor production by P. aeruginosa
Activity on Erwinia Amylovora demonstrated in literature on lactonase
Safety: No toxicity on rats observed up to 10mg/ml
The most active lactonase among all described lactonases
Highly thermostable (Tm = 106 °C),
1,000 times more resistant than the mesophile lactonase to protease
Stable more than 1 year in liquid buffer and more than 5 years after freeze- drying
Fire blights infections