Methods for determining whether a patient will achieve a response after radiation therapy

L'innovation

The invention relates to methods for determining whether a patient will achieve a response after radiation therapy.
In particular, the innovation relates to a method for determining whether a patient suffering from a cancer will achieve a response after radiation therapy comprising the steps of :

1. determining the level of ceramide in a first blood sample obtained from the patient before radiation therapy
2. determining the level of ceramide in a second blood sample obtained from the patient during or just after radiation therapy

The innovation allows to compare the level determined at step 1. with the level determined at step 2 and concluding that
- the patient will achieve response when the level determined at step 2. is higher than the level determined at step 1.
or concluding that
- the patient will not achieve a response when the level determined at step 2. is lower than the level determined at step 1.

Ses bénéfices
Improvement of radiotherapy treatment
Adaptation of treatment vs response

Ses applications
Monitoring of radiotherapy protocol : in particularly in the context of hypofractionated radiation therapy

Stade de développement
IN VIVO - Preuve de concept

Laboratoire de recherche
UMR_S 1232 - CRCINA
Équipe de recherche
Equipe 14 : Endothelium radiobiology and targeting

Propriété intellectuelle associée
EP : EP14305764 - filed on the 05-23-2014
WO - CA,EP,JP,US