New target for Asthma : Inhibitors of RAC1 for inducing bronchodilation

L'innovation
The molecular mechanisms responsible for airway smooth muscle cells (aSMC) contraction and proliferation in airway hyperresponsiveness (AHR) associated with asthma are still largely unknown. The small GTPases of the Rho family (RhoA, Rac1, and Cdc42) play a central role in SMC functions including migration, proliferation, and contraction.
We have identified the major role of RAC1 in aSMC contraction and its involment in AHR associated with allergic asthma. We have demonstrated that allergic asthma-associated excessive bronchoconstriction and AHR is dependent on RAC1 activity.

Ses bénéfices
Prevention of bronchoconstriction and airway hyperresponsiveness
Decrease of pulmonary inflammation
No toxicity nor side effect

Ses applications
Acute asthma
BPCO
Cystic fibrosis

Stade de développement
IN VIVO - Preuve de concept

Laboratoire de recherche
UMR 1087 - THORAX

Équipe de recherche
Equipe III – Signalisation et physiopathologie vasculaire et pulmonaire

Propriété intellectuelle associée
EP : EP17305662.3 - filed on the 06-06-2017
WO